The viral vector vaccine, which was developed in alliance with BIDMC, already obtained emergency use authorisation in the US based on its clinical efficacy data in symptomatic Covid-19 in the US, South Africa, and Latin America.
In the new study, BIDMC’s Center for Virology and Vaccine Research found antibody and cellular immune responses against the SARS-CoV-2 variants of concern, as well as the original strain.
Data showed immune responses generated by Ad26.COV2.S against all variants of the Covid-19 virus, researchers noted.
Study senior author and BIDMC immunologist Dan Barouch said: “The concern is whether SARS-CoV-2 variants may reduce the efficacy of current vaccines that were designed to protect against the original SARS-CoV-2 strain at the beginning of the pandemic.
“These findings therefore have important implications for vaccine protection against SARS-CoV-2 variants of concern.”
In the study, 20 participants aged 18 to 55 years received one or two doses of J&J’s vaccine to assess its immunogenicity.
These subjects were from a multi-centre, randomised, double-blind, placebo-controlled Phase I/II trial analysing different doses and schedules of the vaccine.