Oncology clinical trials in Mexico – Lung Cancer Therapy.

For more than 30 years, LC has remained unchallenged as the most frequent neoplasm in the world, also leads the list in terms of cancer-related mortality.
Oncology clinical trials in Mexico

For more than 30 years, lung cancer (LC) has remained unchallenged as the most frequent neoplasm in the world. Accompanying the high incidence rates, LC also leads the list in terms of cancer-related mortality, and this epidemic is projected to continue both in developed and developing countries. Mexico, located in the Americas region, is populated by 123 million individuals, making it the third most populous country of the Americas, following the United States and Brazil. In terms of economy, Mexico falls in the classification of upper-middle-income economies according to the World Bank. The country is divided into 32 states. Population density averages 61 inhabitants/km2; however, this varies according to the geographic area, from 5967 inhabitants/km2 in Mexico City, to 14 inhabitants/km2 in the northern state of Chihuahua.

The Mexican health care system is divided into a public and a private sector, with an overwhelming 93% of the population treated in the publically funded facilities. These include the Mexican Institute of Social Security (IMSS), which covers 50% of the population, the State Workers Institute for Social Security and Health (ISSSTE), or the most recent Popular Health Insurance (SPS). This last one, also known as “Seguro Popular,” is a voluntary health insurance scheme which was introduced in 2004 to provide coverage for the poor and uninsured. It grew so rapidly that by 2011 nearly 90% of the population was covered; however, it currently does not include LC treatment, which leaves this impoverished sector without treatment options. Only 7% of the population is estimated to hold private sector insurance. Although the system has been successful in providing universal health coverage for the country’s population, there are still many challenges which arise from this fragmented system, which ultimately derive in different standards of care within each institution.

LC Epidemiology in Mexico

According to data from GLOBOCAN, 190,667 incident cancer cases occur in Mexico every year, among which 7811 correspond to LC cases, with a standardized rate of 5.8.

In terms of mortality, a total of 33,781 deaths due to LC occurred in Mexico from 2012 to 2016. In 2016 alone, 7044 deaths were attributable to LC, making this the highest-mortality neoplastic disease in Mexico; further, LC is a sub-diagnosed disease, and therefore this figure might be higher. LC deaths in Mexico are more frequent in men, in a 1.6:1 ratio, older age individuals, with 53% of all deaths presenting in patients older than 70 years of age, and more frequently affect the northern region of the country. Moreover, 80% of all deaths are reported in patients who resided in urban regions. As can be seen from these alarming numbers, LC remains a major public health problem in Mexico; nonetheless, encouraging data has emerged in the last 3 years which evidences the effort currently undertaken to fight this epidemic. The mortality rate has steadily declined from 6.4 in the year 2000 to 5.7 in 2016. Additionally, whereas LC represented 10.8% of all cancer-related deaths 20 years ago, this has decreased to 7.9% currently. It is important to stress that caution must be taken when interpreting these results, particularly when considering the aging population within this country. In fact, absolute numbers of LC cases and deaths are expected to increase substantially in the next years as a result of these characteristics. Following the current world trend, women will lead this increment in mortality. Mexican women tend to have a disease presentation at an earlier age, with a median of 59 years of age at diagnosis.

Screening and Early Detection

The LC burden in Mexico is evident. However, Mexican patients with LC still suffer from shortcomings when considering several aspects pertaining to their health care. For example, there is currently no active public screening program for high-risk populations despite the fact that these risks are well characterized within the national setting. Subjects with known risk factors have the option of paying for screening; however, severe cost-constraints limit the wide implementation of this strategy, along with a considerable demographic impairment due to the fact that in Mexico approximately 20% of the population resides in rural areas, with scarce-to-no access to medical equipment. This in turn restricts performing a timely diagnosis throughout the country. In Mexico, stage I-II lung cancer patients are almost anecdotic, and 98% to 99% of patients are diagnosed with late-stage disease.

In August 2018, a government press release announced the launching of a national screening program for all subjects with tobacco or wood-smoke exposure; however, the economic package of 2019 for public health has left this much needed project in uncertainty.

 

Oncology clinical trials in Mexico

Diagnosis and Staging

Aside from the challenge to perform a timely diagnosis, another important issue is assessing disease stage. Most patients live in areas which lack the medical equipment and field specialists required to correctly assess the disease; therefore, many patients must travel within their state or the country to be properly staged. For example, the availability to perform endobronchial ultrasound-transbronchial needle aspiration is limited throughout the country, which negatively affects the adequate assessment of newly diagnosed patients. The urgent need for medical oncologists in Mexico is well recognized, with approximately 1700 specialists registered, among which 40% reside in three large urban areas (Mexico City, Monterrey, and Guadalajara).

Surgical Approaches

In terms of therapeutic strategies, patients in Mexico have access to surgery; however, most patients who are candidates for surgery will be treated by a cardiothoracic surgeon, rather than by a thoracic oncology specialist. Currently only two centers in the country offer high-specialty training in thoracic oncology (medical and surgical), demographically limiting the training options in order to reap highly specialized, critical physicians in this field. As a consequence, nationwide oncology teams usually lack thoracic oncology field specialists in terms of surgical training, or other disciplines, particularly in decentralized regions. The recently published national guidelines for LC treatment recommend that patients with early-stage LC be offered a lobectomy as a surgical approach, preferably through a minimally invasive procedure. In this regard, video-assisted thoracic surgery is available as an option in highly specialized centers where thoracic oncology surgeons can perform the procedure. It is important to mention that the technology to perform video-assisted thoracic surgery is available nationwide; however, surgeons who meet the strict learning curve to offer a high-quality procedure are scarce, limiting the widespread availability of this technique. Segmentectomy or wedge resections are also available for patients with low pulmonary capacity. Further, all patients who undergo surgery also undergo mediastinum staging, either by mediastinal lymph node sampling or by systematic mediastinal lymph node dissection. Last, for patients with stage IA disease who are not candidates for surgery, radiosurgery is preferred to radiofrequency ablation.

Radiation Therapy

Radiotherapy has been a cornerstone for LC treatment for several decades. For the small proportion of patients who are diagnosed with inoperable stage I disease, guidelines recommend that they be referred to a specialized center with access to stereotactic body radiotherapy, although there are only two cities which currently offer this modality (Mexico City and Monterrey). For the majority of patients who have stage IV disease, radiotherapy might be administered to the primary tumor to improve survival outcomes. As discussed below, patients in Mexico almost never have access to third-generation targeted therapies, due to severe cost-constraints. Therefore, in this population, the role of prophylactic cranial irradiation to delay the development of brain metastases should be adequately appraised, particularly for well-characterized high-risk patient subgroups.

An important limitation in terms of radiotherapy in Mexico is, once again, access. For example, IMSS offers health care to 74 million Mexicans, yet as of 2018 there were only 35 lineal accelerators in the country, and they were all concentrated in nine states, leaving the other 23 states without equipment for this treatment modality.

It is an unfortunate truth that patients with LC in Mexico will generally not benefit from the great advances in the field of thoracic oncology which have arisen in the last 10 years. These conditions highlight the need to pressure authorities to secure availability and access to therapies which have become the standard of care in developed nations.

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 Many of these therapies have been proven cost-effective, and interestingly, in the specific case of LC, survival has been strongly associated with access to greater financial funds; therefore, failure to act upon this urgent matter will relegate LC deaths to poorer states, widening the gap in terms of global health inequalities.

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