Landscape of gastric adenocarcinoma in Latin America.
We provide a mutational landscape of GA highlights:
- a) Germlinepathogenic variants associated with hereditary GA
- b) Germline risk variants associated with sporadic GA
- c) Somatic variants present in sporadic GA in LATAM and analyze how this landscape can be applied for precision medicine.
The analysis displayed that different germline pathogenic variants for the CDH1 gene have been identified for hereditary GA in Brazilian, Chilean, Colombian, and Mexican populations.
An increased risk of developing somatic GA is associated with the following germline risk variants: IL-4, IL-8, TNF-α, PTGS2, NFKB1, RAF1, KRAS and MAPK1 in Brazilian; IL-10 in Chilean; IL-10 in Colombian; EGFR and ERRB2 in Mexican, TCF7L2 and Chr8q24 in Venezuelan population.
The path from mutational landscape to precision medicine requires four development levels:
1) Data compilation
2) Data analysis and integration
3) Development and approval of clinical approaches
4) Population benefits.
Generating local genomic information is the initial padlock to overcome to generate and apply precision medicine.